Well it finally hit me today. Working in Logic X for a couple of hours when playback started glitching, and distorting. Base iMac Pro (8 core, 32gb, Vega 56) running High Sierra 10.13.6.
Sounds like a sample rate sync issue, memory leak or both but you beat me to the punch.
Followup on this it appears that there was some sort of issue with audio interface (or possible user error by me) where the sample rate in Logic was set to a value that isn't supported without the interface and this was causing the freakout. At least I think so as the issue hasn't repeated itself since then. Anyway if something changes I'll post here again.
A number of apps that I use like to reset the sample rate including older versions of Finale and Dragon Dictate. UAD, Digital Performer and Logic have these issues, too.
Some of it is better recently, notably Finale, but I must still be careful.