Just installed Sierra and wanted to see what works. So far from my testing the below work for me.
MOD EDIT: This is a wiki post, which is editable by anyone with the appropriate rights. Please update this post with compatible and incompatible apps to ensure the list is comprehensive. For apps with limited compatibility, please include a link to your post explaining the limitations. The lists are in alphabetical order.
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Compatible
1Password 6
2Do
4D v15.2
Accordance Bible
Adapter
Adium (requires manual connection)
Adobe Acrobat Pro 10
Adobe Acrobat Pro 11.0.16
Adobe Acrobat DC
Adone Acrobat Reader DC
Adobe Bridge CS6
Adobe Creative Cloud
Adobe Illustrator CC 2015.3
Adobe Illustrator CS6 (Needs Java 6)
Adobe Indesign CS6
Adobe Photoshop CC 2015.5
Adobe Photoshop CS6
Adobe Photoshop Elements 8 (ver. 8.0)
Affinty Photo
Airmail 3
Airy YouTube Downloader
Alfred 3
Amphetamine
Apple Remote Desktop
AppZapper
Atom 1.7.4
BackBlaze 4.0.5.934
Back-up Online v16.8.0.16325 (KPN)
Banktivity 5 (formerly iBank)
Bartender 2 (Test Release)
Better Rename 9
BetterTouchTool
BetterSnapTool
BitTorrent Sync
Blackmagic Disk Speed Test
Caffeine
Carbon Copy Cloner Version 4.1.12 (4485)
CARROT Weather
Chatology
Checkbook Pro
Chrome 51.0.2704.84
Cinema 4D R17
Citrix Receiver 12.2.0
Cloudmagic
Colormunki Display (sometimes need a reinstall and re-calibrate)
Commander One
coconutBattery
Coda
Continuity Activation Tool
CrossOver
CustomMenu 2.12
DaisyDisk
Dark Boot 4.0.6
DaVinci Resolve 12
Day One v2
Deliveries 2.0.1
Discord
Disk Inventory X
Disk Sensei
Disk Warrior 5.0
Downie 2.3.9
Drobo Dashboard
Dropbox
Dropshare
Duel (moved in incompatible)
Duet Display (using the latest iOS and OS X versions, after removing the OS X kext Extension and restarting, and installing the latest app version - 1.5.8.8 - and restarting; these instructions were related by the Developer); previous comments: (with iOS 10, although a bit choppy) (DP5>GM causes app to try & reinstall, won't reinstall)
EazyDraw 8.3.1 (new version)
Elmedia Player
Evernote
EaseUS Data Recovery Wizard
Fan
Fantastical 2
Fetch 5.7.5
Final Cut Pro X (working fully as of GM)
FileZilla
Firefox
Fluid (and apps made with Fluid)
Flux
Folx Download Manager
Font Book (fixed in second beta)
F5 Big-IP Edge Client (VPN) - Now works in Public Beta 2
GhostTile
Google Drive Desktop App
Handbrake
HardwareGrowler
Hardware Monitor
HoudahSpot 4.2.1
iBackup (for iAccount iOS) - needs legacy java
iBooks
iDrive 3.4.0.15
iFlicks 2
iSkySoft iTube Studio 5.7.1
iStat Menu 5.11
iStat Pro
IVI Pro
iWeb
Itsycal
Keynote
Kindle (as of second Sierra seed)
Kodi
LastPass
Letterspace v1.6.4
Little Snitch Nightly build 3.7 (
https://www.obdev.at/products/littlesnitch/download.html)
Logic Pro X
LogMeIn
Logitech Control V3.9.5 (
Updated/Fixed Sept 22 2016)
V3.9.3/V3.9.3 Don't recognize my Logitech Performance Mouse (Logitech Unifying Software V1.2.315 works). What this means is that my Logitech Mouse is Recognized, but just the left and right buttons work along with the scroll wheel. None of the other buttons can be programmed Because Unifying Software does not recognize the mouse.
Magnet
MacMiner
Maintenance 2.2.0 or later
Malwarebytes
MAMP Pro 4
Microsoft Office 2008 (as of 16A294a)
Microsoft Office 2011 (All Applications)
Microsoft Office 2016
Microsoft OneDrive Personal (as of Public Beta 4)
Microsoft Remote Desktop
Mindnode
Minecraft 1.10
Moom
Mountain
MPlayer OSX Extended
MySQL Workbench 6.3.6
Nik Collection
Numbers
OmniFocus 2.5.3
OmniGraffle 6.0.4 (quite old)
OmniGraffle 5.4.4 (even older)
OnyX 3.2.0 or later
OpenEmu
Opera
Outside 1.1.10
ownCloud Client 2.2.0
Pages '09
PaintCode 2.4.2
Parallels 11.2.0
PDF Expert
Pinegrow Web Editor v2.9
Pixelmator (Magic Wand causes crash every time it is used, other than that no other observed issues)
Plex
PMT( PropertyMaintenanceTracker )
Pocket 1.6.2
Polar FlowSync 2.6.4
PopClip
PrintCheck
Pyware versions 8.0.1 and higher (due to using Oracle's Java and not the old MRJ)
Quicken 2007
Quicken 2015
Quicken 2016
QuickSleep 1.0.4
Quiver 3.0.2
Radio Silence
Reeder
Remotix
Scansnap Manager
ScreenConnect
Scrivener
ScummVM
Shazam
Sketch 3.8.3 by Bohemian Coding
SketchUp 2016
Skitch 2.7.8
Skype 7.30 (274)
Slack 2.0.3
Snapz Pro X 2.6
Spark 0.2.4.7
Spotify (although slow to launch and ever the memory hog)
Steam (now works on GM - previous comment: Code signature error, needs to be manually signed)
Stickies 10.0
StuffIt Expander
Subler
SuperDuper
SyncMate
TechTool Pro 8 & 9
Telegram (As of 6/20 update is unstable:
https://macos.telegram.org)
Telegram Desktop
Text Expander 5.1.4
Text Wrangler
Textual 5
The Unarchiver
Transmission
Transmit
Trim Enabler
TunnelBear
TunnelBlick
Tweetbot 2.4 (though sometimes, tweets appear blank or empty... closing/restarting Tweetbot fixes the issue temporarily.)
Twitter
Ulysses (as of v2.6)
VMT ( VehicleMaintenanceTracker)
Vivaldi Web Browser (1.2.490.39) (64-bit)
VLC
WhatsApp Desktop
WiFi Explorer (latest version 2.2, 7 September 2016)
Yummy FTP
xAct
XLD
Limited Compatibility
Aperture 3.6 (limitations listed in Sierra release notes)
Acrobat Pro 11.0.16 - Will not Print. Fixed in PB4.
CleanMyMac 3 will prompt to install a beta release that supports Sierra (3.5b2)
DxO OpticsPro Elite 10.5.4: image work area reduced to a ⅓ in size, hardly workable this way. Feature control switches are functional but covered by label text. DxO support just confirmed the issue and it won't update version 10 and one has to migrate to DxO 11. Support ticket #105791.
Epson Printers: Scanning ICA Driver (5.8.6): no more multi-page PDF scanning. Scans one page only per output doc. Every new scan must be refreshed with a preview scan.
Fusion 8.1.1 (see
this post)
gfxCardStatus (displays GPU status, but will always force discrete GPU since gfxCardStatus "requires" the discrete GPU)
GIMP (Default language changed, now stops loading)
Goban (igo game) Crashes constantly under 10.12, but is better under 10.12.1. The "Info" pane still does not work correctly, limiting many function, such as switching players from black to white, etc. The free version of this app is so old it probably won't be updated.
Hazel (some rules do not work)
iTunes 10.4.1 Warning at startup, but plays music fine. Have not tried store or signing in.
Line (Voice calling causes "App not responding" and skips audio)
Logic Pro 9.1.8 (can crash intermittently)
MacPorts
- neither the package for El Capitan, nor the port binary within that package, is compatible with Sierra
- it's necessary to build from source
Screenflow 5 and 6 (opens but nothing shows up when recording)
Simple Comic (will not install latest update but reads CBR files okay)
Sonos (Desktop) - Crashes if left open when computer goes to sleep, otherwise, functionality works as expected.
Splashtop Business (installs but will not always connect to remote computers, closing and restarting the app seems to fix this temporarily)
uTorrent (can crash in certain circumstances)
VMware Fusion 8 (Turn of 3D acceleration if you get an "Internal Error." **works in Public Beta 2)
Incompatible
3D Coat
Adobe Dreamweaver CS5 (crashes on launch)
Adobe Dreamweaver CS6 (must reinstall Java 6, opens and functions, crashes on Save As...)
Adobe Illustrator CS6 (installer error, if update from prior OS, make work after reinstall Java 6)
Adobe InDesign CC (installs, but has some rendering issues when dragging objects)
Adobe Photoshop CS5 (crashes on close)
Adobe Photoshop CS6 (installer error, make work if update from prior OS)
Apptivate
AVG AntiVirus (doesn't open)
AVG Cleaner (crashes at launch)
BOX Sync (brings up Console, floods with errors, doesn't work at all)
BusyCal (crashes at launch)
Canon EOS Utility 2.14.20 - program starts but does not connect to Camera anymore. No more photo import or camera remote control. Essential functions disabled therefore.
Carbon Copy Cloner 4.19 (installs and opens for use but does not actually backup)
CCleaner (does not open)
Cleanup SMB mess (icon has slash through it, Sierra throws error when launching)
Contacts (Apple's Application) Crashes FOR SOME at launch
Disk Warrior (launches and works for a while but crashes in the end before replacing the rebuilt directory)
EazyDraw 7 (crashes at launch)
ESET Cyber Security Pro 6.2.6.0 (not working when copied with Migration Ass., can't clean install)
EtreCheck (crashes during scan)
Final Draft 9 (crashes at launch) (Update to 9.0.9 fixes problems)
Freemacsoft LiteIcon 3.6.3 (Error message at launch even when SIP is disabled)
Greek Radio (icon has slash through it, Sierra throws error when launching)
GPGTools (not working with Sierra yet, they are working on it at @
https://gpgtools.org)
GPSPhotoLinker (with 10.10 and 10.11 it required manual install of Perl 5.10 and deactivation of System Integrity Protection (csrutil) but now stopped working at all with 10.12 (
http://www.earlyinnovations.com/forum/viewtopic.php?f=2&t=2513&start=10)
GutenPrint (current version does not work and is disabled by the macOS installer)
Identify 551 (developer has announced that he has ceased development on this program, as well)
Karabiner (needs major changes, not coming anytime soon)
Little Snitch 3.6.3 (see nightly build instead
https://www.obdev.at/products/littlesnitch/download.html)
Movist (crashes after some minutes)
MPlayerX
Online Bible 4.2.1 (crashes with Internal Error due to undocumented function in Sierra GM)
Patterns (regex app from the MAS - marked as incompatible)
Pulse Secure 5.2r2 (backend dsAccessService seg faults when run)
Pyware versions 8.0.0, 7, 6, and lower (due to Apple's MRJ Java--not able to be installed on 10.12)
Quicken Essentials for Mac 1.7.4 (icon has slash through it, Sierra throws error when launching)
RapidWeaver 7 (Opens projects and appears to work but crashes when previewing Site) - Working after update to 7.0.4
Razer Synapse 2.0. (Loads but can't detect device(s))
Safari Technology Preview 9.1.2
Seil (needs major changes, not coming anytime soon)
SIMBL (SafariStand etc.)
Splashtop Streamer (installer will crash on fresh installs, but will stream if previously installed on El Cap then updated to Sierra)
SyncTwoFolders 2.19 (Crashes after selecting destination or target folder)
Yosemite Disk Utility patched to run on El Capitan (crashes at launch)
Microsoft OneDrive (Crashes at Launch) -- works for me -- works as of PB4
Western Digital Disk Tools (Complains about needing to be launched from Applications folder)
WhatsApp Desktop (always recommends moving to Application folder when it is already there, and will lose login details prompting QR scans every time OS restarts) -- ChitChat works for me
WriteRoom 2.5.1 (marked as incompatible)
ZenMate (makes initial VPN connection then disconnects)
