Looking at various discussions over the years on backup issues, you'll find as many solutions as there are users.
I am paranoid as hell, and I don't trust RAID, never have never will. Spoke to an Apple guy on his recent efforts to rebuild one after a crap, and it was brutal.
I always ask one question of myself: "What would I lose that will force me to blow my brains out if I lost it?" Then I build my strategy from there. I can describe briefly what I do, then you can ask that question to yourself maybe?
This is primarily home use, but at work I have the same concept in place.
I am responsible for some incredibly important stuff, and if lost, I'll soon be asking "Want fries with that?".
At home my tower has dual 1TB drives. The second I use for Time machine. It's never failed me, but it's not enough. Also in the tower is another drive that I use CCC daily for critical data. That's still not enough as I always say one needs to alternate locations. So I also do a daily backup of critical data to a Time Capsule. Nope, not enough. For my home business data I backup to the business iDisk account. Still not enough. I also backup that same data to my personal iDisk account. Both methods use Apple's Backup utility. Works well. But that's not all. I have a MyBook World 1TB that ALL data goes to weekly, and also for file transfers to a partner in my home business, along with "working files" to the company iDisk. Think that's enough? Nope. I have two external Firewire drives. Every week I make a complete image of my main drive, then take that drive somewhere else. I alternate drives every other week. THEN I occasionally burn DVD's of my photo's and critical files and store them in another part of the house.
Insane huh? Perhaps, but at least I can sleep at night.
Been looking at the Drobo due to nice write-up's, but it's still a RAID, and it's in the same room. My house burns, I'm dead in the water.
At work I look at the issue the same way, but use different tools, mostly the server version of Retrospect. I've been using that for 10 years and it's never failed me. I don't do catalogs, just file-level copies. I alternate backups to several locations daily, weekly and monthly of critical files. I don't care about the server itself, as they can be rebuilt in a half hour. Then of course once a week I take the SIS database (my main baby) offsite on DVD or FW drive.
So I guess you have to choose a method that best suits your needs, and one that will let YOU get a good nights rest.