My Leopard DVD is from Apple. My G5Quad has a 1 GB SATA and a 2 GB SATA, (one Western Digital Black and the other a Seagate), both standard HDD.My BR Quad and my GER Quad both run and work flawlessly with a Quadro FX4500 perfectly. And with all sorts of other graphics cards, flashed and stock (X1900 XT, multiple X1950 XTs, GeForce 7800 GTX 512 etc.).
If Tiger runs graphically-intensive software with perfection, thus probably excluding the possibility of it being a hardware problem, the first thing I question is your Leopard install. Where is the install DVD sourced from? Is your 2TB disk an HDD or an SSD? (I have had data corruption issues with the former, never had any with the latter.)
Leopard is good stuff. Might want to keep looking into why it isn't working, until it's working. I would also try investigating with only 2 RAM sticks installed, if all else fails.
I have a total of 16GB RAM, I tried it with 2GB, 4GB, 8GB, and 16GB.
I also ran the Apple Hardware Test and it reported no errors.
After 10 total tries, it is why I gave up.