This was discussed extensively when the 2018 Mini was first released. Yes, scaled resolutions are definitely a problem on the 2018 Mini, especially if you only have 8gb. Fifteen pages of discussion here:
I'm getting the i5 Mac Mini and will probably stay at 8 gigs of RAM for a while. I buying this computer as a desktop replacement for media consumption and word processing for the next 6-8 years. I was dreaming of getting something like the LG 27UK850 4K monitor and scale it at 1440p so that...
forums.macrumors.com
I stopped following that thread long ago, but IIRC, upgrading to 16gb helped people who were using 4k screens. But I don't know how much it will help if you're using some odd resolution. Again, just from memory, the theory was that scaled resolutions cause the processor to run hot which eventually leads to CPU throttling and reduced performance. I believe there are other old threads about this as well.
I'm still using my 2018 Mini very heavily, especially with a Windows 10 virtual machine. Performance has always been good for me, but I have 64gb of RAM. And, having read these discussions before purchasing, I was determined NOT to use scaled resolutions. So, I got a 32 inch BenQ QHD screen which I run at the native resolution of 2560x1440. This gives me a user interface with large text that looks good to my old eyes without any scaling.