It’s not so much an issue on the iPad, as it’s a two-handed device by nature, and a larger screen means more room for error. It’s an issue on the iPhone, since I’m left-handed by default, and even on my iPhone 12 mini it can be a stretch to reach the top right corner of the screen, say, to access Control Center or answer an incoming call from the banner.
But I will say that I have yet to find a competing product that matches the features of VoiceOver or AssistiveTouch, both of which I use frequently. I personally wish Apple would bring Hover Text over to the iPad from the Mac, as this would negate the need for me to use VoiceOver while still allowing me to use the iPad and Magic Keyboard combo in a wider variety of settings, beyond just sitting at a desk or table where center-screen is steady and at eye level.