A lot of people are wondering whether their current Mac will support this monitor or not.
If your Mac has Thunderbolt 1/mDP: Yes, but only at 30 Hz, which is fine for videos but a little choppy for computer use or gaming. I don't recommend dropping that amount of money on a monitor you'll only use at 30 Hz, unless you plan to upgrade your Mac in the not-so-distant future.
If your Mac has Thunderbolt 2: Yes, up to 60 Hz as long as OS X "whitelists" this monitor for use with Multi-Stream Transport (MST). Anandtech found the 24" version of this monitor does not work with MST under OS X (limiting the refresh rate to 30 Hz), but it's just a matter of time before Apple updates OS X with better 4K support and an updated MST whitelist. Meanwhile, it should work fine at 60Hz under Windows 8.1.
If you own another device with DisplayPort: Make sure it has DisplayPort 1.2 in order to use this monitor's MST feature and reach 60Hz, otherwise you're stuck at 30Hz.
If you own another device with HDMI: If you have HDMI 1.3 or earlier, it won't work at all. If you have HDMI 1.4, it'll work, but you're stuck at 30Hz. Only HDMI 2.0 will allow 60Hz UHD 4K and this monitor doesn't appear to include it. HDMI 2.0 is expected to debut in Q2 2014.
I do hope OS X is updated with better 4K support soon.
One little thing. HDMI 2.0 is already out. The Panasonic TX-L65WT600 was the first released product in 2013.
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