Yes, that home button (plus a screen protector) makes it easier to get a purchase on it to pull out of a pocket too!Easy fit in pants or shirt pocket; easy in and out; comfortable.
In any case, I never use my iPhones without a case or two hands. One-handed use is just asking for a disaster! It's so much easier to hold the phone in one hand and tap out messages or URLs — or tap on icons or links — with the other.
I'm constantly using my phone while doing something else with the other hand -- whether it's carrying a heavy bag, holding a subway pole, holding a dog leash, or stirring a pot of chili. One-handedness is a must-have.