On this 21/5" core2duo 3.06gHz imac (shipped with 10.6), I saw this with Apple's Magic Mouse, Apple's wired single-button (white) mouse, and a 2-button microsoft wheel mouse. I've tried all 3 mice with different drivers, including M$ drivers, USB overdrive, and Apple's built-in drivers. I was able to see this error with ALL combinations of driver/mouse, so it's not related to brand/wireless capability. The only similarity in setups is that they are all *optical* mice. I do not see this behavior at all using a logitech trackball (on another 10.6.3 box - xeon tower).
*yanks out hair like everyone else*